Background: Histoplasmosis is one of the invasive fungal infections and presents with symptoms mainly in the\nlungs. Disseminated histoplasmosis (DH) is rare and its lesions in the gastrointestinal tract are even uncommon. The\nconcomitant involvement of the upper and lower gastrointestinal tract has never been described in the\nimmunocompetent individuals.\nCase presentation: A 44-year-old immunocompetent Chinese man presented with fever, hepatosplenomegaly,\nfungal esophagitis and protuberant lesions with central depression and erosion along the mucous membrane of\nthe colon. The patient was diagnosed as disseminated histoplasmosis by gastrointestinal endoscopy.\nConclusions: Histoplasmosis should be taken caution in patients with fever and hepatosplenomegaly. Actions\nshould be taken to avoid its disseminated infection associated high mortality.
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